Almost everyone knows the story of the discovery of one of the most famous psychedelics, lysergic acid diethylamide. In 1938, Swiss chemist Albert Hofmann researched a number of lysergic acid compounds, and only five years later the psychotropic properties of the compound LSD-25, which has now...
Effect of cannabis on nausea and vomiting
Cannabinoid receptors are found along gagging pathways in the peripheral system and the CNS, including areas associated with the generation of nausea and vomiting (particularly the postrema and dorsal vagal complex areas). Cannabinoid agonists probably...
Introduction
Cannabis and its derivatives have been found to affect many gastrointestinal processes by affecting the endocannabinoid system (ECS) with anti-inflammatory, antinociceptive, and antisecretory effects. It is believed that some gastrointestinal disorders can be treated with...
Different ways of consuming cannabis provide different amounts of cannabinoids to the body. There is a difference between smoking a joint, a bowl, a bong or a blunt and eating an edible or taking a small amount of tincture (or oil) that contains THC. There is also a difference when you consume...
Introduction
The epigraph to the article is not chosen by chance. First of all, Aldous Huxley was a great fan of "expanding" his consciousness with the help of various hallucinogenic substances. In fact, the name of the synthetic drug "soma" from Huxley's immortal novel refers to the mysterious...
READ --->> An endless and colorful world of hallucinations (PART I)
Alpha rhythm suppression and hallucinations
Alpha rhythm suppression is the most reliable correlate of the psychedelic state and can serve as a marker of the visual intensity of the psychedelic experience. However, the alpha...
Why do the walls "breathe"; why does the paint on the walls of the toilet suddenly begin to leak, even though major repairs have probably not been done in this communal apartment since its foundation; why do any patterns begin to repeat; why does the image still seem to freeze for a second in...
The compulsive desire to eat, eat and eat again after consuming cannabis, even if the stomach does not agree with it, is both a curse and a salvation. It all depends on the purpose of using this plant. And the newly discovered mechanism of cannabinoid action on the brain turned out to be...
A special molecular switch influences addictive (dependent) behavior and determines the strength of the body's response to addictive drugs.
A group of researchers from Heidelberg and Sorbonne Universities (Paris) came to this conclusion during experiments on mice (cocaine was used as a drug)...
The "Research chemicals" section already has opiates that are potentially easy to synthesize and have very interesting morphine-like effects with minimal side and unwanted effects. The minimization of side effects is due to many factors, which I will describe in more detail. μ-opioid receptors...
To answer the question, we need to define some receptor dynamics and corresponding effects.
It has been established that after a single administration of classical psychedelics there is a massive and prolonged desensitization of 5-HT2a receptors, which leads to the phenomenon of tachyphylaxis -...
People who are immersed in self-analysis (by temperament) or who study the mental structure from a professional point of view have always been attracted to the topic of psychoactive substances, which on the one hand is a culture-modifying phenomenon (by analogy with disease-modifying therapy)...
Introduction
The dose-dependence of THC has become mainstream in both the narrow scientific circles of psychopharmacologists and the general consumer community. This variation in effects can be explained by the unimaginable multidirectional functions of the cannabinoid brain system. Many still...
Hi!
Please write specifically the names of the psychoactive substances you want to use, as well as the exact way you want to use them.
I'm happy to talk about safe doses and explain everything
Yes, that is indeed fear. But don't forget that this fear is caused by the body's multiple regulatory systems, among them adrenal cortex hormones, which cause severe vasoconstriction of the coronary vessels, which can lead to acute myocardial ischemia and cause sudden cardiac death. I'm not...