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  1. Brain

    50 Years of "Scientific" Silence

    Almost everyone knows the story of the discovery of one of the most famous psychedelics, lysergic acid diethylamide. In 1938, Swiss chemist Albert Hofmann researched a number of lysergic acid compounds, and only five years later the psychotropic properties of the compound LSD-25, which has now...
  2. Brain

    Is cannabis a panacea for digestive diseases? (PART II)

    Effect of cannabis on nausea and vomiting Cannabinoid receptors are found along gagging pathways in the peripheral system and the CNS, including areas associated with the generation of nausea and vomiting (particularly the postrema and dorsal vagal complex areas). Cannabinoid agonists probably...
  3. Brain

    Is cannabis a panacea for digestive diseases? (PART I)

    Introduction Cannabis and its derivatives have been found to affect many gastrointestinal processes by affecting the endocannabinoid system (ECS) with anti-inflammatory, antinociceptive, and antisecretory effects. It is believed that some gastrointestinal disorders can be treated with...
  4. Brain

    Bioavailability of different ways to use cannabis

    Different ways of consuming cannabis provide different amounts of cannabinoids to the body. There is a difference between smoking a joint, a bowl, a bong or a blunt and eating an edible or taking a small amount of tincture (or oil) that contains THC. There is also a difference when you consume...
  5. Brain

    Maybe this world is another planet’s hell

    Introduction The epigraph to the article is not chosen by chance. First of all, Aldous Huxley was a great fan of "expanding" his consciousness with the help of various hallucinogenic substances. In fact, the name of the synthetic drug "soma" from Huxley's immortal novel refers to the mysterious...
  6. Brain

    An endless and colorful world of hallucinations (PART II)

    READ --->> An endless and colorful world of hallucinations (PART I) Alpha rhythm suppression and hallucinations Alpha rhythm suppression is the most reliable correlate of the psychedelic state and can serve as a marker of the visual intensity of the psychedelic experience. However, the alpha...
  7. Brain

    An endless and colorful world of hallucinations (PART I)

    Why do the walls "breathe"; why does the paint on the walls of the toilet suddenly begin to leak, even though major repairs have probably not been done in this communal apartment since its foundation; why do any patterns begin to repeat; why does the image still seem to freeze for a second in...
  8. Brain

    Why does THC make you want to eat?

    The compulsive desire to eat, eat and eat again after consuming cannabis, even if the stomach does not agree with it, is both a curse and a salvation. It all depends on the purpose of using this plant. And the newly discovered mechanism of cannabinoid action on the brain turned out to be...
  9. Brain

    Molecular dependence switch

    A special molecular switch influences addictive (dependent) behavior and determines the strength of the body's response to addictive drugs. A group of researchers from Heidelberg and Sorbonne Universities (Paris) came to this conclusion during experiments on mice (cocaine was used as a drug)...
  10. Brain

    μ-opioid receptor heterodimer agonists are a priority for RC

    The "Research chemicals" section already has opiates that are potentially easy to synthesize and have very interesting morphine-like effects with minimal side and unwanted effects. The minimization of side effects is due to many factors, which I will describe in more detail. μ-opioid receptors...
  11. Brain

    Can classic psychedelics cause addiction? (notes of a Pharmacologist)

    To answer the question, we need to define some receptor dynamics and corresponding effects. It has been established that after a single administration of classical psychedelics there is a massive and prolonged desensitization of 5-HT2a receptors, which leads to the phenomenon of tachyphylaxis -...
  12. Brain

    On rare hallucinogens and the long/terrible path of the psychonaut

    People who are immersed in self-analysis (by temperament) or who study the mental structure from a professional point of view have always been attracted to the topic of psychoactive substances, which on the one hand is a culture-modifying phenomenon (by analogy with disease-modifying therapy)...
  13. Brain

    Neuropsychological effects of THC (notes of a Pharmacologist)

    Introduction The dose-dependence of THC has become mainstream in both the narrow scientific circles of psychopharmacologists and the general consumer community. This variation in effects can be explained by the unimaginable multidirectional functions of the cannabinoid brain system. Many still...
  14. Brain

    Protonitazene, Metonitazene & N-Desethylisotonitazene

    Hi! Please write specifically the names of the psychoactive substances you want to use, as well as the exact way you want to use them. I'm happy to talk about safe doses and explain everything
  15. Brain

    Mescaline

    yeah :geek:
  16. Brain

    MT2 mediated pyschedelic visuals

    Thanks for the interesting info!
  17. Brain

    DMT for subcutaneous injection?

    Smoked free dmt or smoked changa. If we are talking about injections, then only in the form of fumarate.
  18. Brain

    Extended release

    Be sure to send it, I'll be glad to talk to you, bro.
  19. Brain

    Lethal dose of a-PVP (research)

    Yes, that is indeed fear. But don't forget that this fear is caused by the body's multiple regulatory systems, among them adrenal cortex hormones, which cause severe vasoconstriction of the coronary vessels, which can lead to acute myocardial ischemia and cause sudden cardiac death. I'm not...
  20. Brain

    why am i still tired when taking speed

    Unfortunately, urine pH cannot be considered a major controlling indicator for this problem, but your point is a good one, bro
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