pyridine alpha arylation of diphenylacetonitrile under phase transfer conditions;
https://sci-hub.hkvisa.net/https://doi.org/10.1016/S0960-894X(01)00443-7
The original synthesis of Desoxypipradrol as written in the patent linked below is effected by the condensation of Diphenyl acetonitrile with 2 Bromo pyridine followed by hydrolysis of the nitrile and decarboxylation and then catalytic hydrogenation of the pyridine ring with Raney Nickel. A...
I have found a promising research paper: https://sci-hub.hkvisa.net/https://doi.org/10.1081/SCC-120005418
It uses acetonitrile as co solvent, I would much rather use N methyl pyrrolidone, https://sci-hub.hkvisa.net/10.1002/047084289X.rm240.pub2
Do think think that the reaction will fail?
Do any chemists here have information pertaining to the solubility of benzaldehyde in a variety of organic solvents like dimethyl formamide, dimethyl sulfoxide, acetonitrile, N methyl pyrrolidone? If I find any information relevant to this question I will post it below.
Search up M. B. Tolmie Masters Thesis - Australian Federal Police, it is a pdf related to the leukart reaction.
https://www.sciencemadness.org/talk/viewthread.php?tid=144546&page=3
William can you tell me if carbamyl groups are labile under friedel crafts conditions because it is known that carbamate esters are reduced to the N alkyl group upon reduction for example the methyl carbamate (S)-methyl (1-phenylpropan-2-yl)carbamate would be reduced to (S) methamphetamine, it...
While reading Erowid (https://erowid.org/archive/rhodium/chemistry/phenylacetone.html) A pathway stood out which was a wittig reaction between benzaldehyde and the triphenylphosphonium salt of alpha chloro ethyl methyl ether, the product of this reaction is an enol methyl ether which can be...
There is prevailing interest in 4 Methylaminorex and its derivatives, in part owning to it's scarcity. Pharmacological study's suggest that the rank order of potencies for 4 Methylaminorex enatiomers is trans-4S,5S > cis-4S,5R ~ cis-4R,5S > trans-4R,5R and racemic Trans methylaminorex is...