4-MMC (mephedrone) synthesis. Complete video tutorial.

[Marvin "Popcorn" Sutton]

The reaction with NMP takes 15-20 minutes, it can be replaced by Dimethyl sulfoxide, Dimethylformamide or Sulfolane.
But NMP is the best choice.
For 1g of 2-bromo-4-methylpropiophenone you take 3ml of benzene, if not completely dissolved you can add 1-2ml. The reaction takes much longer in benzene. If you don't heat the mixture, reacts for ~24 hours, depending on the amount of ketone.

 

[ELOELO]

This will be my first time due to my lack of experience in chemistry, I would like to make sure of something. Starting with 2b4m, is it enough that I dissolve them in 300ml of benzene and, after complete dissolution, add 200ml of methylamine? Methylpyrrolidone is not required in my case?

 

[btcboss2022]

Hello I did it with DMF and Toluene.

 

[zuidmen]

Ufff I dont remember now I did it once and long time ago sorry.

 

[btcboss2022]

Ufff I dont remember now I did it once and long time ago sorry.

 

[vig212]

Same problem iam also facing. In fact the final product is bringing tears to eyes and is burning on tongue

 

[TheVacuumGuy]

Well, it should

 

[Hank Schrader]

We brominate with the absorption of hydrobromic acid. Then we replace with methylamine and carry out the selection with further purification.
My synthesis takes approximately 3 hours from start to salt isolation. + crystallization.
Tried to crystallize in different ways. Nitrogen, thermoses, drying cabinets.

 

[riderofapocalypse]

why u are using old ukrainian shop pictures?

 

[w2x3f5]

Bromination with hydrobromic acid is not convenient to scale, too much volume is needed (8.3 mol per liter only HBr), bromine is not convenient due to smell, bromine succinimide is too expensive and need Tos acid. You can use bromine + oxidizing agent, then the amount of bromine is half as much and there are no acid clouds...
Best way use cheap sources of bromine.
Do not make crystals weighing more than 5kg, it is very difficult to break with a hammer.

 

[TheVacuumGuy]

What you are saying is bromine isn't convenient due to smell, NBS due to price, HBr due to volume.
But you end up saying: oxydizing agent + cheap sources of bromine..

Half of bromine or cheap source smells exactly as worse

 

[w2x3f5]

Bromides do not smell and the price is low.

 

[marty€mcfly]

I have access to a lab & lab equipment now so, h don’t use it anymore but, it’s nice to share!

 

[Albert A]

How did the prescription change under more favorable conditions in the lab?

does the type of solvent ( DCM or NMP) if keeping the heat limit not affect the cleanliness of the final product?

 

[PolandoEmingarnte]

on dcm on is 2 other ways made

 

[Albert A]

what is the difference between them?

 

[marty€mcfly]

I can’t say what changes the color chemically because I could be wrong but each solvent needs a different care. I just know the methods I use, and keeping a constant temperature with an ice bath keeps the color light.

“I can’t say that the lab makes it better because I’ve struck gold in less professional settings”. I -can-recant-that!

 

[PolandoEmingarnte]

dont need any lab equpment to made 4mmc/3mmc/3cmc/4cmc/apvp/bk-mdma/nep/pentedron/4mec.

 

[antrax]

If after recrystallization of bk-MDMA HCI the crystals have a brown-orange color, it means that they have impurities, then how can I make the crystals transparent?

 

[TheVacuumGuy]

Ater more than 6 months reading and getting familiar with chemistry, buying all equipment and reagents (except bromine, i made myself), i'm about to follow this video and see if i can get results from it.
1 thing remains mysterious.. Bromine+benzene are added to the drip funnel...
Why is benzene with bromine added to a flask of benzene? Is the addition of benzene in the funnel to keep the bromine in control ?

 

[khanasgar452@]

can someone tell me the CAS no of all this Chemicals please​

 

[Muktika]

Is it a bad idea to use Methylamine 38%? Can I increase its concentration by evaporating it in the kitchen, or is it better to look for 40% in the store?

 

[ChemistryStudentPL]

Where can I buy - N-methylpyrrolidon

 

[Tsigger]

I made an MMC in a benzene/NMP solvent system, and after acid treatment, I ended up with two layers. The bottom layer is red, which I assume is bromine. Did this happen because of the water in the hydrochloric acid? Should I separate them into two parts, or should I combine them and put them in the freezer?

 

[Tsigger]

I didn’t add acetone, just MMC freebase in benzene, and I dripped in 30% HCl at pH 5.5. I added the acid slowly. Could acetone be the issue? I forgot, because I usually acidify with DCM+water, so acetone didn’t come to mind. How did you acidify the beauty in the picture? Thank you very much.

 

[Dr. MMX]

the beauty in the picture is result of crystalisation process
doesnt matter which path in sytnehsis you go, its onyl visual output

 

[Dr. MMX]

i ve successfully received crystals in the final when i did a lot of mistakes and used acetone to acidification. It just happened - unfortunate things between. Still output like that.
You should analize what you do

 

[WillD]

If you use aq. hydrochloric acid, you need a solvent that binds water. This is acetone or alcohol (ethanol, propanol)