reduction

  1. GhostChemist

    Phenylpropanolamine Hydrochloride Reduction to Amphetamine Using I2 and H3PO2

    Amphetamin Synthesis from phenylpropanolamine hydrochloride with reduction using I2 and H3PO2. Starting reagents and materials 4.84 g phenylpropanolamine hydrochloride 10.4 g I2 9.4 ml H3PO2 20-50 ml H2O 50 ml 25% NaOH (15-20 г NaOH) 3 g sodium thiosulfate 250-300 ml DCM 30-50 g Na2SO4...
  2. P

    Question regarding mdp2p Nabh4 reduction

    After nabh4 addition is complete and mixed for a few hours after can you let the mix sit for a few hours and the freebase oil layer will rise to the top and can be seperated? this eliminates the need for dcm or toluene extraction but does effect yield.
  3. G

    Amphetamines via Al/Ga reductive amination Al/Hg alternative

    hey folks, to encourage a more ecological sustainable method for amine reduction than Al/Hg, i want to present you the aluminium-gallium-amalgan method. Basically you can just use al-ga amalgan instead the mercury one and that's it. Actually a ratio of 1:1 between reactant and amalgan, while a...
  4. victorplum

    Wolff-Kishner reduction, large scale, feasible or just suicide?

    As per title: I was trying to come up with a stereo-selective synthesis, but I'm stuck at one point where I have to remove a carbonyl. Turning it into an alcohol would vanish the selectivity goal. Now, wherever I look for information it's just people warning about preferring any other way is...
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