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Or... What if the starting material /was/ Ketamine? Breaking the double bond would be tricky but separating the two cyclic groups beforehand would save the Chlorine (possibly the amine too), so you break the double bond, demethylate, dehydroxylate and then join the two afterwards... actually...

I've been looking through journals and while I'm an amateur chemist with a lot of experience in the field...what if the cyclohexyl ring was stabilised by the two double bonds before being treated to the 2-Cl-phenyl. You'd need to bind them though and the methyl bridge in the main synths would...

Ok, so I need an alternative K synth where I can attach the Oxo at the 4 position rather than the 2. The only synth that seems remotely able to do is the new Iranian synth but swapping out the Oxophenyl for a 1,4-dioxo-phenyl ring and then cleaving the oxo with a deoxidizing agent after...