You can add your methylamine HCL to 2-bromo ...in any solvent and add slowly correct amount NaOH in Water 1:5, then Methylamine HCL will turn in methylamine gas or in Water ....
Sorry, I made little mistake. Please add 400-415 g of 37% HCL acid for 1 kg of Br, not 390 ml becouse it is a little to much. ( g not ml ) ! If you are doing small amount you can give 400g if amout is bigger use better 410-415 g HCL for 1 kg br becouse reaction is a little exotermic and a little...
DCM is also good but remember organic layer will be at the bottom and water layer will be UP:
1) Disolve 1 kg or 2-Br-3-chloropropiophenone or in 4 l DCM
2) Add to this 2 l of Methylamine 40% and mix it 4 h. If you are working with larger quantities for exaple 50 kg of 2br3 you have to give...
yeld 74% was good, but in final product you have a lot of methylamine HCL. Final product with a lot of methylamine HCl is difficult to recrystalization and to get nice big needles, only small cristalline powder. To the reaction you use to much methylamine, should be max x2 to 2Br4 so 2 l, and to...