Amphetamin Synthesis from phenylpropanolamine hydrochloride with reduction using I2 and H3PO2.
Starting reagents and materials
4.84 g phenylpropanolamine hydrochloride
10.4 g I2
9.4 ml H3PO2
20-50 ml H2O
50 ml 25% NaOH (15-20 г NaOH)
3 g sodium thiosulfate
250-300 ml DCM
30-50 g Na2SO4...
Starting reagents and materials
100 ml H2O
7.21 g THF
15.1 g KBrO3
13.6 g KHSO4
14 g Na2S2O5 dissolved in 150 ml H2O
150 ml H2O
250-300 ml DCM
50 g Na2SO4
3.38 g NaHCO3 dissolved in 15 ml H2O
3-neck flask 1000 ml
Thermometer
High efficiency double circuit reflux
Magnetic stirrer
Cold...
norm result!
evaporate it for crystallization. wash using Et2O or ethylacetate or petroleum ether (may be with small portion of acetone) on the vacuum filter.
recrystallize (optional) from alcohol or in other pure solvents
Starting Reagents and Materials
6 g Synthetic ephedrine hydrochloride racemic
12 g I2
10.8 ml H3PO2 (50%)
20 ml H2O
50 ml 25% NaOH (15-20 г NaOH)
3 g sodium thiosulfate
250-300 ml DCM
30-50 g Na2SO4
100 ml Petroleum ether
HCl gas
100 g NH4Cl
25 ml H2SO4 83%
Flasks 250 and 500 ml
Glasses
Funnels...
Starting reagents and materials
6 g Synthetic ephedrine hydrochloride racemate
1.8 g Red phosphorous (P)
12 g Iodine (I2)
100-150 ml H2O
3 g Sodium thiosulfate (Na2S2O3)
24 ml 25% NaOH
250-300 ml DCM
100 ml Petroleum ether
HCl gas
100 g NH4Cl
25 ml H2SO4 83%
Flasks 250 and 500 ml
Beakers...