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Stage one: 1-Phenylpropan-1-one Bromination
Stage two: Preparation and Washing of Methcathinone Hydrochloride
Stage three: Methcathinone Hydrochloride Formation

Edit: 6:20 - 125 ml of ethyl acetate
https://bbgate.com/threads/synthesis-of-methcathinone-hydrochloride-from-propiophenone.9410
methcathinone synthesis is identical to 4mmc, only we use 2b1m. Here you can clearly see that the free base has been overheated and a red-green free base remains, which means there is no complete reaction with bromoketone. Yellow means pure free base. There is too little DCM in the amination reaction. Moths disagree. The rest is fine. Ps. methactinone should be as white as milk after adding hydrochloric acid. then you don't need to clean it with acetone and you have pure methatynon hcl
 
methcathinone synthesis is identical to 4mmc, only we use 2b1m. Here you can clearly see that the free base has been overheated and a red-green free base remains, which means there is no complete reaction with bromoketone. Yellow means pure free base. There is too little DCM in the amination reaction. Moths disagree. The rest is fine. Ps. methactinone should be as white as milk after adding hydrochloric acid. then you don't need to clean it with acetone and you have pure methatynon hcl
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.
 
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I'm so happy to see this. While I know the synthesis of methcathinone and mephedrone are extremely similar, I'm excited for methcathinone to receive more attention.

It seems like an interesting drug, just no popular, but I bet if this gets going and it is actually a decent drug, it might become a bit more popular.
 
Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenone.
 
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Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenon4I doubt
I doubt this will ever take off except perhaps in very large scale.

You are basically doing a multistep synthesis to get to a precursor for meth. You'll still have to react the ephedrine as per typically done, after resolving it...so you don't even save on the resolution step.

P2p will always be king unless the black market starts producing ephedrine via bacteria like done in the pharmaceutical industry

Otherwise, it's more steps, using more methylamine, and more work than synthesizing p2p, imo
 
Hello does anyone have any information regarding synthesis of methamphetamine using "hypo cook" synthesis route.By the way I am really struggling a lot to find an convenient method to synthesize methamphetamine the issue is with the p2p I am not able to find those chemicals needed to synthesize p2p here in india I am fed up with this I will be frank I am not an chemist but I really do wanna learn how to synthesize methamphetamine I been into this for like months but still I can't find an convenient synthesis route I messaged a lot of members in this forum but none replied I don't even have btc wallet to purchase ethyl2chloropropionate and other precursors to synthesize p2p. I don't have enough of money for it please let me know if anyone have "hypo cook" cook synthesis route atleast give me an reply
 
Hello does anyone have any information regarding synthesis of methamphetamine using "hypo cook" synthesis route.By the way I am really struggling a lot to find an convenient method to synthesize methamphetamine the issue is with the p2p I am not able to find those chemicals needed to synthesize p2p here in india I am fed up with this I will be frank I am not an chemist but I really do wanna learn how to synthesize methamphetamine I been into this for like months but still I can't find an convenient synthesis route I messaged a lot of members in this forum but none replied I don't even have btc wallet to purchase ethyl2chloropropionate and other precursors to synthesize p2p. I don't have enough of money for it please let me know if anyone have "hypo cook" cook synthesis route atleast give me an reply
I'm from India ,I will be happy to assist you .Ask me anything
 
Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenone
As an African yes you are right,The most Populer drugs 1) Crystal Meth 2) methaqualone (Extremlely Cheap) 3)CAT
 
I'm so happy to see this. While I know the synthesis of methcathinone and mephedrone are extremely similar, I'm excited for methcathinone to receive more attention.

It seems like an interesting drug, just no popular, but I bet if this gets going and it is actually a decent drug, it might become a bit more popular.
They are 1 and the same thing.
 
Thank you for your great video... I have a question, what is the simple method to crystallize methcation?
 
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.
 
Hello, good time, chemist friends.
In the test, with what type of pump do we remove liquids from the container? I don't have a pump and I am planning to get one, please help me. How does this pump work?
 
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with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.
The video shows the method of synthesis that the chemist chose. You can make your own video about how you obtained 100 kg of methcathinone. Show it to us so that we can evaluate your method.
 
Preparation of 35-40% methylamine aqueous solution.
Could you please tell me what the mixing ratio is?
thank you
 
Bo
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is per

with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.
Boss explain this step,
'' with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.''
1. Question: are you referring to DCM after acidification with HCl? Where DCM got separated from water layer?
2. Question; are referring to DCM before acidification?
3. Question; Do you mean that heating reaction mixture with DCM @40°c for 2hours and avoid the need to stirring at room temperature for 24hours on conversation of methcathinone to ephedrine, please expert guide us..
4. Question; if there is need for, to save TIME, then the heating should be in water bath, since DCM is highly flammable.

Note;
I cherish time, using 2hours to mix 24hours is good step.
 
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Bo



Boss explain this step,
'' with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.''
1. Question: are you referring to DCM after acidification with HCl? Where DCM got separated from water layer?
2. Question; are referring to DCM before acidification?
3. Question; Do you mean that heating reaction mixture with DCM @40°c for 2hours and avoid the need to stirring at room temperature for 24hours on conversation of methcathinone to ephedrine, please expert guide us..
4. Question; if there is need for, to save TIME, then the heating should be in water bath, since DCM is highly flammable.

Note;
I cherish time, using 2hours to mix 24hours is good step.
DCM is not flammable. Try it
 
How
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.
Please how Do I skip the 24 hours stirring time after 12 hours methyla
Mine stage
 
How

Please how Do I skip the 24 hours stirring time after 12 hours methyla
Mine stage
Hello, you can try adding all the methylamine solution at once and slightly heat it (reaction temperature should not exceed 44°c) cooling might be required if you add all the methylamine at once.
 
Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4
VI6uSH3CbU


Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly
 
Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4
VI6uSH3CbU


Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly
 
Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4
VI6uSH3CbU


Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly
 
The end amine turns red if you add it all at once.
I don't have concrete data to prove my claim but I tend to believe that adding all the methylamine at once is more efficient so far I've done several such synthesis and my yields tend to be higher if I do so, this being said I'm working on a 25g(of bromopropiophenone) and it might not be applicable on a bigger sfale. The red colour is usually a sign of oxidation and formation of by-products.
 
methcathinone synthesis is identical to 4mmc, only we use 2b1m. Here you can clearly see that the free base has been overheated and a red-green free base remains, which means there is no complete reaction with bromoketone. Yellow means pure free base. There is too little DCM in the amination reaction. Moths disagree. The rest is fine. Ps. methactinone should be as white as milk after adding hydrochloric acid. then you don't need to clean it with acetone and you have pure methatynon hcl
Bro u know we can use other substances to brom in this reaction if brom is out off our access?
 
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.
Bro do u know other substances for hbr in this reaction can be we use if hbr doesn't exist?
 
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.
Hello, I used the video method, but with a higher scale and small changes After hydrogenation, I washed with sodium thiosulfate solution Also, I washed the free base with sodium thiosulfate before the hydrochloride step Also, I reacted for two hours at 40 degrees Celsius like you quoted And also to be sure, I stirred for another 3 hours at room temperature

bromation photo
methylamine added photo
mcat hydrochloride photo
And then I washed a small part of it with acetone 😉
300grams product from 370 ml propiohenone
 
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulti

C
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.
Do u know other alternative to hbr in this reaction can we use hcl and zn in for this reaction bro
 
Hello, I used the video method, but with a higher scale and small changes After hydrogenation, I washed with sodium thiosulfate solution Also, I washed the free base with sodium thiosulfate before the hydrochloride step Also, I reacted for two hours at 40 degrees Celsius like you quoted And also to be sure, I stirred for another 3 hours at room temperature

bromation photo
methylamine added photo
mcat hydrochloride photo
And then I washed a small part of it with acetone 😉
300grams product from 370 ml propiohenone
Can we use hcl instead of hbr in this reaction or other substances?
Bro
 
How we can made hbr in other reaction to prepare enough hbr to this reaction
Plz guide me🤔
 
I just want to learn this ephedrine synthesis method from methcathinone and perfect I'm it, that is my dream job.. please who can attest about the yield, is it profitable, who has really tried it, the issue of add methylamine at once and cooling rather than adding in 12hours time and the issue of heating @,40°c for 2hours instead of 24hours reaction time, please who has really done this, the last I did it my yield was discouraging. Friends and teachers let's share ideas and knowledge,
 
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